Lymphocytic Choriomeningitis (LCM)

Lassa Fever

New world Arenavirus

Arenaviridae

  • single-stranded RNA
  • ๊ด€๋ จ 6๊ฐœ์˜ ์ธ์ˆ˜๊ณตํ†ต์ „์—ผ๋ณ‘
  • ๋ฏธ์ฃผ์ถœํ˜ˆํ˜•? 4๊ฐœ๋ฅผ Tacaribe complex๋ผ๊ณ  ํ•จ.
VirusHostDisease์ง€์—ญ ๋ฐœ์ƒ
Arenaviruses of Old World
LCM virusHouse mouseLCM์œ ๋Ÿฝ, ๋ฏธ๊ตญ
Lassa virusMultimammate mice์„œ์•„ํ”„๋ฆฌ์นด
American Hemorrhagic fevedr (New World, Tacaribe complex)
Junin virusLaucha chicaAHF์•„๋ฅด์  ํ‹ฐ๋‚˜, ํŒŒ๋ผ๊ณผ์ด
Machupo virusLaucha grandeBHF๋ณผ๋ฆฌ๋น„์•„
Guanarito virusCotton ratVHF๋ฒ ๋„ค์ˆ˜์—˜๋ผ
Sabia virus?Brazilian hemorrhagic fever๋ถ๋ถ€ ๋ธŒ๋ผ์งˆ
Whitewater Arroyo virusWood ratU.S. hemorrhagic fever์ฝœ๋กœ๋ผ๋„, ๋‰ด ๋ฉ•์‹œ์ฝ”
Old World : ์œ ๋Ÿฝ, ์•„ํ”„๋ฆฌ์นด, ์•„์‹œ์•„, ์˜ค์ŠคํŠธ๋ ˆ์ผ๋ฆฌ์•„ ..
New World : ๋ถ์•„๋ฉ”๋ฆฌ์นด, ๋‚จ์•„๋ฉ”๋ฆฌ์นด

Zoonoses (by New World Arenavirus)

  • ์„ค์น˜๋ฅ˜์— ์˜ํ•ด ์‚ฌ๋žŒ์— ๊ฐ์—ผ
  • ์„ค์น˜๋ฅ˜์—๋Š” ๋งŒ์„ฑ๊ฐ์—ผ
Junin virusAHF
Machupo virusBHF
Guanarito virusVHF
Sabia virusBrazilian hemorrhagic fever

์น˜๋ฃŒ

  • ์ค‘ํ™” ํ•ญ์ฒด์˜ ์ด๋ฅธ ์ ์šฉ
  • ribavirin
  • symptomatic treatment

Lassa Fever

  • ์„œ์•„ํ”„๋ฆฌ์นด์˜ ์ „์—ผ๋ณ‘

  • ์น˜๋ช…๋ฅ ์€ 15%

  • 2000๋…„๋„, ์—ฌํ–‰์ž๊ฐ€ virus๋ฅผ carry

  • human to human์ด ๋นˆ๋ฒˆํ•˜๋‹ค (ํŠนํžˆ ๋ณ‘์›์—์„œ)

์ง„๋‹จ

  • BSL-4 lab์—์„œ ์ง„ํ–‰ํ•ด์•ผ
  • Vero์—์„œ ๋ฐ”์ด๋Ÿฌ์Šค ๋ถ„๋ฆฌ